Alzheimer’s disease
Comparison versus Tacrine in Patients with Alzheimer’s disease
  Efficacy of idebenone in the treatment of Alzheimer’s disease
  Nerve Growth Factor synthesis stimulators in Alzheimer’s disease
  In the treatment of dementia of the Alzheimer type
  Cognitive enhancement therapy for Alzheimer’s disease
  Protection from beta amyloid-induced oxidative stress
  Protection from beta amyloid-induced memory deficits and neurotoxicity
  A study of 2 doses of idebenone in the treatment of Alzheimer’s disease
  A two year study of idebenone treatment for Alzheimer’s disease
  Stimulates NGF synthesis in the treatment of Alzheimer’s disease
  Animal model study of Nerve Growth Factor and Alzheimer’s disease
Leber’s hereditary optic neuropathy (LHON)
Does it shorten the time to visual recovery in Leber’s hereditary optic neuropathy?
  Improvement in a patient with Leber’s hereditary optic neuropathy (LHON)
Friedreich’s ataxia
Reduced heart thickness on 6 of 8 Friedreich’s ataxia patients
  Is effective at controlling cardiac hypertrophy in Friedreich’s ataxia
  Notable cerebellar improvement in early stage Friedreich’s ataxia
  Improvement in mitochondrial cardiomyopathy with idebenone
  Effect of idebenone on cardiomyopathy in Friedreich’s ataxia
  Friedreich’s ataxia and frataxin
  And reduced cardiac hypertrophy in Friedreich’s ataxia
  Heart function is improved by idebenone in Friedreich’s ataxia
  Mitochondrial dysfunction in Friedreich’s ataxia
  Frataxin: Its role in iron metabolism and Friedreich’s ataxia
Improves cerebral mitochondrial oxidative metabolism in MELAS
  In young patients with mitochondrial encephalomyopathy (MELAS)
  Therapy in Mitochondrial encephalomyopathy (MELAS)
  And Mitochondrial encephalomyopathy (MELAS)
  Successful therapy with idebenone in Mitochondrial encephalomyopathy (MELAS)
  Long-term treatment with idebenone and riboflavin in a patient with MELAS
Use in age-related cognitive disorders
  Protects hippocampal neurons against beta amyloid neurotoxicity
  Functions as a potent protective hepatocyte antioxidant
  Neuroprotective effects can be attributed to its antioxidant properties
  Inhibition of brain mitochondrial swelling
  Suppression of cold ischemia/reperfusion injury of liver endothelium
  Ability to eliminate a nitroxide radical in the rat
  Interaction with respiratory complexes of heart mitochondria
  Effect on serotonin release and serotonergic receptors in rats
  Protects against damage in organ preservation solutions
  Protects against excitotoxic degeneration in cultured cortical neurons
  Protects against disorders due to cerebral hypoxia or ischemia
  Protects against toxicity induced by low density lipoprotein
  Attenuates neuronal degeneration induced by excitotoxins
  Augments long-term potentiation in hippocampal slices in the guinea pig
  Effects on stroke-prone, hypertensive rats
  Effect on cerebral glucose utilization in rats
  Effects on acetylcholine levels in the brains of rats with cerebral ischemia
  Protective effect of idebenone against hypoxia in mice
  Improves learning and memory impairment induced in rats
  Effects on neurological deficits in stroke-prone rats
  Effects on memory induced impairment in rats
  Effects on cerebral blood flow in rats with cerebral ischemia
  Effects on ethanol-induced neurological disorders
  Inhibition of brain mitochondrial swelling
  Inhibition of platelet aggregation
  Effects on monoamine metabolites of patients with dementia
  Effects on metabolism of monoamines and cyclic AMP formation in rats
  Effects on impairment of radial maze learning in cerebral embolized rats
  Effect on lipid peroxidation in rat brain homogenate
  Effects on muricidal behavior in rats with raphe lesions
  Inhibitory effect on vascular lesions in hypertensive rats