http://www.idebenone.info Idebenone Research Fri, 19 Sep 2008 09:57:57 +0000 http://backend.userland.com/rss092 en Idebenone, a drug with antiaging benefits by Robert Mason Ph.D. When Coenzyme Q10 was found to produce heart and energy improvement, it soon became apparent that it was a most important supplement Now there is also a synthetic variant available called idebenone, it has all the qualities of CoQ10 but with an even ... http://www.idebenone.info/idebenone-the-ultimate-anti-aging-drug Idebenone - A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders. Gillis JC, Benefield P, McTavish D. Adis International Limited, Auckland, New Zealand. Drugs Aging 1994 Aug;5(2):133-52 ABSTRACT Idebenone is a benzoquinone compound which has been investigated in elderly patients with dementia. Its precise mechanism(s) of action remains unknown, but ... http://www.idebenone.info/idebenone-use-in-age-related-cognitive-disorders Idebenone protects hippocampal neurons against amyloid beta-peptide-induced neurotoxicity in rat primary cultures. Hirai K, Hayako H, Kato K, Miyamoto M. Pharmaceutical Research Division, Takeda Chemical Industries Ltd., Osaka, Japan Naunyn Schmiedebergs Arch Pharmacol 1998 Nov;358(5):582-5 ABSTRACT The application of amyloid beta-peptide (Abeta) 1-40 (10 microM) caused neurodegeneration of hippocampal neuronal cells, as indicated by the release ... http://www.idebenone.info/idebenone-protects-hippocampal-neurons-against-beta-amyloid-neurotoxicity The effect of idebenone, a coenzyme Q analogue, on hydrophobic bile acid toxicity to isolated rat hepatocytes and hepatic mitochondria. Shivaram KN, Winklhofer-Roob BM, Straka MS, Devereaux MW, Everson G, Mierau GW, Sokol RJ. Department of Pediatrics, University of Colorado School of Medicine, Denver, CO USA ABSTRACT Oxidant stress induced by hydrophobic bile acids has been implicated ... http://www.idebenone.info/idebenone-functions-as-a-potent-protective-hepatocyte-antioxidant Antioxidant properties of idebenone. Mordente A, Martorana GE, Minotti G, Giardina B. Institute of Biological Chemistry, Catholic University School of Medicine, Rome, Italy. Chem Res Toxicol 1998 Jan;11(1):54-63 Abstract Idebenone is a synthetic analogue of coenzyme Q that is currently employed in the treatment of vascular and degenerative diseases of the central nervous system. There is ... http://www.idebenone.info/idebenone-neuroprotective-effects-can-be-attributed-to-its-antioxidant-properties Inhibition of brain mitochondrial swelling by idebenone. Suno M, Nagaoka A. Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan Arch Gerontol Geriatr 1989 May;8(3):299-305 ABSTRACT The effects of idebenone on the swelling of rat brain mitochondria were studied. When FeCl3 was added to a mitochondrial suspension, a pronounced mitochondrial swelling occurred accompanied by the production ... http://www.idebenone.info/idebenone-inhibition-of-brain-mitochondrial-swelling-2 Suppression of leukocyte-enhanced cold ischemia/reperfusion injury of liver endothelium with the benzoquinone antioxidant idebenone. Schutz E, Wieland E, Hensel A, Niedmann PD, Dreiss A, Armstrong VW, Schuff-Werner P, Oellerich M. Abteilung Klinische Chemie, Georg-August-Universitat, Gottingen, Germany. eschuetz@med.uni-goettingen.de Clin Biochem 1997 Dec;30(8):619-24 ABSTRACT OBJECTIVE: Despite the large body of evidence for a major role of neutrophils and oxidant ... http://www.idebenone.info/idebenone-suppression-of-cold-ischemiareperfusion-injury-of-liver-endothelium An analysis of the intracerebral ability to eliminate a nitroxide radical in the rat after administration of idebenone by an in vivo rapid scan electron spin resonance spectrometer. Yokoyama H, Tsuchihashi N, Ogata T, Hiramatsu M, Mori N. Institute for Life Support Technology, Yamagata Technopolis Foundation, Japan. MAGMA 1996 Sep-Dec;4(3-4):247-50 ABSTRACT Electron spin resonance (ESR) measurements ... http://www.idebenone.info/idebenone-ability-to-eliminate-a-nitroxide-radical-in-the-rat The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria. Esposti MD, Ngo A, Ghelli A, Benelli B, Carelli V, McLennan H, Linnane AW. Centre for Molecular Biology and Medicine, Monash University, Melbourne, Victoria, Australia. Arch Biochem Biophys 1996 Jun 15;330(2):395-400 ABSTRACT We have studied the interaction of idebenone with the ... http://www.idebenone.info/idebenone-interaction-with-respiratory-complexes-of-heart-mitochondria Effect of idebenone on in vivo serotonin release and serotonergic receptors in young and aged rats. Scavini C, Rozza A, Lanza E, Favalli L, Racagni G, Brunello N. Institute of Pharmacology, University of Pavia, Italy. Eur Neuropsychopharmacol 1996 May;6(2):95-102 ABSTRACT The effect of idebenone on the serotonergic system was evaluated in the aging rat by measuring the ... http://www.idebenone.info/idebenone-effect-on-serotonin-release-and-serotonergic-receptors-in-rats