Inhibitory effect of idebenone on vascular lesions in hypertensive rats.

Nagaoka A, Shino A, Kakihana M, Iwatsuka H.

Jpn J Pharmacol 1984 Nov;36(3):291-9

ABSTRACT

The effects of a novel compound, idebenone on cerebral and renal vascular changes were examined in stroke-prone spontaneously hypertensive rats (SHRSP) and in rats with experimentally induced hypertension. Idebenone (35 mg/kg/day, p.o.) significantly inhibited the onset of cerebrovascular lesions (stroke) and the elevation of blood pressure in SHRSP with mild hypertension. A higher dose (2 X 50 mg/kg/day, p.o.) clearly delayed the onset of both stroke and proteinuria without any effect on the blood pressure in SHRSP with severe hypertension. In DOCA-salt hypertensive rats, idebenone (2 X 5 or 2 X 25 mg/kg/day, p.o.) dose-dependently inhibited decreases in body weight and water balance and the development of cerebral and renal vascular changes. These results suggest that idebenone inhibits the development of stroke and renal vascular lesions in hypertensive rats.