The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria.

Esposti MD, Ngo A, Ghelli A, Benelli B,
Carelli V, McLennan H, Linnane AW.

Centre for Molecular Biology and Medicine,
Monash University, Melbourne, Victoria, Australia.
Arch Biochem Biophys 1996 Jun 15;330(2):395-400

ABSTRACT

We have studied the interaction of idebenone with the energy-conserving complexes of the respiratory chain in beef heart mitochondria and compared its energetic efficiency with that of other analogs of coenzyme Q. idebenone is a very effective substrate for succinate:Q reductase and ubiquinol:cytochrome c reductase, but it is clearly a poor substrate for NADH:Q reductase (complex I). Indeed, idebenone is a strong inhibitor of both the redox and proton pumping activity of complex I, showing effects in part similar to those of coenzyme Q-2. However, the mechanism of idebenone interaction with complex I may be different from that of Q-2 because of its different sensitivity to inhibitors. The possible relevance of the present findings to the therapeutic use of idebenone is discussed.