Protective effects of idebenone on vascular endothelial cells against toxicity induced by oxidatively modified low density lipoprotein.

Naito M, Hayashi T, Yamada K, Asai K, Yoshimine N, Iguchi A.

Department of Geriatrics,
Nagoya University School of Medicine, Japan.
Artery 1993;20(6):314-23

ABSTRACT

We examined the protective effects of idebenone, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone, on the cytotoxicity of oxidatively-modified low density lipoprotein (oxLDL), using cultured vascular endothelial cells from fetal bovine aorta. When the cells were incubated with idebenone, the toxicity of oxLDL was inhibited dose-dependently (10(-7)-10(-5) M). When cells were preincubated with idebenone, the toxicity of oxLDL was inhibited only at a high concentration (10(-5) M). However, iidebenone had no significant effects on copper-induced modification of LDL. The protective effects of idebenone on oxLDL-induced endothelial toxicity may be beneficial for the inhibition of the development of atherosclerosis in the brain and other arterial systems.